The first time this took place(update, notification/broken Cloudron services), was on a VPS hosted by SSDnodes - thus constituting my first experience with the infamous IPv6 bug, and as a result of a reboot request(notification), following a Cloudron update.
In this particular case, and though I did confirm the IPv6 issue, I chose not to repair, in-favor of rolling-back(snapshot), for the sake of brevity.
Fast-forward to this round - and on a rather fresh Cloudron installation, on Proxmox VM w/different provider, I'd add that both instances would constituted what I'd call vanilla, in-that they were both simple mail servers, with a single SOGo application for webmail.
Beyond that, there were no modifications made on either instances beyond the addition of nftables.
NB, the first instance was on a network with IPv6 support, whereas the second(more recent), is on an IPv4 only network.
PS, if you would like additional details on this particular incident, please don't hesitate to ask as the details remain fresh on my purview, and moreso, that I would really like to help in improving the Cloudron experience for others