Someone from the EspoCRM Forum discoverd that i need to enable smtp auth. With this i can send mails.
Background for not enabling smtp auth:
We use Office365 as Mail System. Because we run some Apps in our cloudron i marked the Server as trusted host in the office365 exchange system. With this all the apps can send Mails without entering Mail Server data.
Topic is solved for me.
For Reference:
https://forum.espocrm.com/forum/bug-reports/52380-can-t-send-emails-over-office365