Occasional timeouts when sending emails
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For some time now, I’ve been getting timeouts when sending emails with Thunderbird. I then have to send the email again. Sometimes I even need a third try. It’s a bit annoying. My main concern here is whether you also experience this occasionally. If so, I’d blame it more on the mail server of my Cloudron instance. If not, I’ll need to check my local network.

Cloudron v.9.0.13
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Haven't encountered such timeouts from thunderbird, unless the network is actually flaky.
Maybe check if both ipv4 and ipv6 are setup but only one works? Could be that thunderbird (probably relying on the system's network interface selector) sometimes picks one of the two which resolves but does not route.